Description

(S)-Methyl 4-Hydroxy-3-Methylbutyrate is a high-value chiral intermediate and building block in organic synthesis. This compound matters for its role as a key precursor in the production of pharmaceuticals, particularly statin drugs and other active pharmaceutical ingredients (APIs) requiring specific stereochemistry. Industries that need it include pharmaceutical R&D, fine chemical manufacturing, and biotechnology for developing novel therapeutics and high-purity specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of statin drugs (e.g., Atorvastatin, Rosuvastatin) and other cardiovascular APIs.
• Fine Chemical Synthesis: Used in the preparation of complex molecules requiring the (S)-4-hydroxy-3-methylbutyrate moiety for biological activity.
• Biocatalyst & Enzyme Substrate: Serves as a substrate or precursor in enzymatic reactions and biotransformation studies.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective chemical reactions to introduce chirality.
• Nutritional Supplement Research: Investigated as a potential precursor or analog in the research of bioactive compounds like HMB (β-hydroxy β-methylbutyrate).
• Fragrance & Flavor Intermediate: Utilized in the synthesis of certain esters and lactones for specialty aroma chemicals.

Basic Information

Product Name	(S)-Methyl 4-Hydroxy-3-Methylbutyrate
CAS No.	138306-24-8
Molecular Formula	C6H12O3
Molecular Weight	132.16 g/mol
Synonyms	(S)-Methyl 3-Hydroxy-3-methylbutyrate; (S)-Methyl 3-Hydroxyisovalerate; (S)-Methyl 4-Hydroxy-3-methylbutanoate; (S)-HMB Methyl Ester; (S)-3-Hydroxy-3-methylbutyric acid methyl ester; (S)-3-Hydroxyisovaleric acid methyl ester; Methyl (S)-4-hydroxy-3-methylbutyrate; (S)-Methyl β-hydroxy β-methylbutyrate
EINECS	Contact for details

Quality Control

Our (S)-Methyl 4-Hydroxy-3-Methylbutyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.