Description

5-Hydroxymethyl-3-Methylpyrrolidin-2-One is a high-purity, functionalized lactam building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a hydroxymethyl group and a chiral center, makes it a versatile precursor for the development of complex pharmaceutical intermediates and fine chemicals. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create novel bioactive molecules with enhanced properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in neurologic and metabolic disorder research.
• Agrochemical Synthesis: Used as a building block for developing novel pesticides and herbicides with specific stereochemical requirements.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, including advanced polymers, ligands, and catalysts.
• Bioconjugation & Linker Chemistry: The reactive hydroxymethyl group enables its use in creating linkers for drug delivery systems and bioconjugates.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective reactions to construct complex molecular architectures.
• Research & Development: A valuable compound for academic and industrial R&D in medicinal chemistry and synthetic methodology development.

Basic Information

Product Name	5-Hydroxymethyl-3-Methylpyrrolidin-2-One
CAS No.	138078-58-7
Molecular Formula	C6H11NO2
Molecular Weight	129.16 g/mol
Synonyms	3-Methyl-5-(hydroxymethyl)pyrrolidin-2-one; (5R)-5-(Hydroxymethyl)-3-methylpyrrolidin-2-one; (5S)-5-(Hydroxymethyl)-3-methylpyrrolidin-2-one; 5-Hydroxymethyl-3-methyl-2-pyrrolidinone; 3-Methyl-5-hydroxymethyl-2-pyrrolidone; HMP; Chiral Hydroxymethyl Lactam
EINECS	Contact for details

Quality Control

Our 5-Hydroxymethyl-3-Methylpyrrolidin-2-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccated environment after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% (Specific enantiomer available)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.