Description

6-o-(Triisopropylsilyl)-D-Glucal is a protected carbohydrate derivative, specifically a silyl ether of D-glucal, widely used as a versatile chiral building block in organic synthesis. Its primary value lies in providing a stable, protected hydroxyl group that enables selective functionalization at other positions on the sugar ring, a critical step for constructing complex molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries engaged in the development of novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of nucleoside analogs, glycosidase inhibitors, and other bioactive molecules.
• Glycochemistry Research: Used in the preparation of complex oligosaccharides, glycoconjugates, and glycomimetics for drug discovery and biological studies.
• Agrochemical Synthesis: Serves as a precursor for chiral ligands and active ingredients requiring specific stereochemistry.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances where precise stereocontrol is necessary.
• Process Chemistry: Utilized in route development and scale-up for APIs (Active Pharmaceutical Ingredients) due to its stability and handling properties.
• Academic & R&D: A valuable reagent for methodological development in asymmetric synthesis and carbohydrate chemistry.

Basic Information

Product Name	6-o-(Triisopropylsilyl)-D-Glucal
CAS No.	137915-37-8
Molecular Formula	C15H30O5Si
Molecular Weight	318.48 g/mol
Synonyms	6-O-Triisopropylsilyl-D-glucal; 6-O-TIPS-D-glucal; (3aR,5R,6S,6aR)-6-[(Triisopropylsilyl)oxy]-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan; D-Glucal, 6-O-[(1,1-dimethylethyl)dimethylsilyl]-; TIPS-D-glucal; 1,5-Anhydro-2-deoxy-6-O-triisopropylsilyl-D-arabino-hex-1-enitol
EINECS	Contact for details

Quality Control

Our 6-o-(Triisopropylsilyl)-D-Glucal is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and optical rotation measurement, to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.