Description

(2R,3S)-1,2-Epoxy-3-(Benzyloxycarbonyl-Amino)-4-Phenylbutane is a high-purity chiral epoxide building block of significant importance in asymmetric synthesis. This compound serves as a critical intermediate for the production of complex pharmaceutical actives, particularly protease inhibitors and other bioactive molecules. It is essential for research and development laboratories, process chemists, and manufacturers in the pharmaceutical and fine chemical industries who require reliable, stereochemically-defined intermediates for advanced synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of HIV protease inhibitors and other antiviral drugs.
• Peptidomimetic Research: Used in the construction of peptide analogs and enzyme inhibitors due to its epoxy and protected amino functionality.
• Asymmetric Synthesis: Employed in stereoselective ring-opening reactions to introduce amino alcohol motifs with high enantiomeric purity.
• Fine Chemical Production: Serves as a building block for the manufacture of specialized catalysts and ligands used in organic synthesis.
• Academic & Contract Research: Utilized in medicinal chemistry programs and process development for new chemical entities (NCEs).
• Custom Synthesis: A starting material for the contract manufacturing of proprietary drug candidates and advanced intermediates.

Basic Information

Product Name	(2R,3S)-1,2-Epoxy-3-(Benzyloxycarbonyl-Amino)-4-Phenylbutane
CAS No.	137515-66-3
Molecular Formula	C18H19NO4
Molecular Weight	313.35 g/mol
Synonyms	(2R,3S)-1,2-Epoxy-3-[(benzyloxy)carbonyl]amino-4-phenylbutane; N-Cbz-(2R,3S)-Epoxybutane-1,4-diamine Phenyl Derivative; (2R,3S)-N-Carbobenzoxy-3-amino-1,2-epoxy-4-phenylbutane; (2R,3S)-3-[(Benzyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane; (2R,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane; Cbz-Amino Epoxy Phenylbutane; Z-Amino Epoxy Phenylbutane Stereoisomer
EINECS	Contact for details

Quality Control

Our (2R,3S)-1,2-Epoxy-3-(Benzyloxycarbonyl-Amino)-4-Phenylbutane is manufactured under strict quality systems to ensure batch-to-batch consistency and high stereochemical purity. The product undergoes rigorous analytical testing, including chiral HPLC, to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support compliance with cGMP, ICH guidelines, and relevant pharmacopeial standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to maximize stability. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.