Description

6-(Trifluoromethyl)-4-Aza-2-Oxindole is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring both an oxindole scaffold and a strategically positioned trifluoromethyl group, makes it a critical intermediate for developing novel bioactive molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of kinase inhibitors, receptor modulators, and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the biological activity-enhancing properties of the trifluoromethyl group.
• Chemical Biology Probe Development: Employed as a scaffold for creating tool compounds to study enzyme function and biological pathways.
• Material Science Research: Investigated as a building block for specialty polymers and advanced organic materials with unique electronic properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	6-(Trifluoromethyl)-4-Aza-2-Oxindole
CAS No.	136888-36-3
Molecular Formula	C8H3F3N2O
Molecular Weight	200.12 g/mol
Synonyms	4-Aza-6-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one; 6-(Trifluoromethyl)-1,3-dihydro-2H-pyrrolo[3,4-b]pyridin-2-one; 2-Oxo-6-(trifluoromethyl)-2,3-dihydro-1H-pyrrolo[3,4-b]pyridine; 6-Trifluoromethyl-4-azaoxindole; 1H-Pyrrolo[3,4-b]pyridin-2(3H)-one, 6-(trifluoromethyl)-; 136888-36-3; 6-Trifluoromethyl-4-aza-2-oxindole
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)-4-Aza-2-Oxindole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, identity, and impurity profiles. We support cGMP compliance for advanced applications and can provide material for research and development through to pre-clinical stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.