Description

Ethyl 2,2-Difluoropentanoate is a high-purity fluorinated ester building block of significant interest in advanced organic synthesis. This compound matters for its role as a versatile precursor in the development of pharmaceuticals, agrochemicals, and specialty materials, where the introduction of fluorine atoms is critical for modulating biological activity and material properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate difluoroalkyl motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs) containing difluoromethylene groups, which can improve metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, pesticides, and fungicides where fluorine substitution enhances efficacy and environmental persistence.
• Fluorinated Material Precursor: Serves as a building block for specialty polymers, liquid crystals, and surface-active agents requiring specific fluorochemical properties.
• Organic Synthesis Reagent: Employed in nucleophilic substitution, condensation, and cross-coupling reactions to introduce the 2,2-difluoropentanoyl moiety.
• Chemical Research & Development: A valuable tool for medicinal chemistry and process chemistry teams exploring structure-activity relationships (SAR) in new chemical entities.

Basic Information

Product Name	Ethyl 2,2-Difluoropentanoate
CAS No.	136854-22-3
Molecular Formula	C7H12F2O2
Molecular Weight	166.17 g/mol
Synonyms	Ethyl 2,2-Difluorovalerate; 2,2-Difluoropentanoic Acid Ethyl Ester; Pentanoic Acid, 2,2-Difluoro-, Ethyl Ester; Ethyl 2,2-Difluoropentanoate; Ethyl α,α-Difluoropentanoate; 2,2-Difluorovaleric Acid Ethyl Ester; Ethyl 2,2-Difluorovalarate
EINECS	Contact for details

Quality Control

Our Ethyl 2,2-Difluoropentanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.08 g/cm³
Refractive Index (n20D)	~1.380 - 1.390

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.