Description

Pyrrolidine, 1-(2-Fluoro-3-Methyl-1-Oxopentyl)-2,5-Dimethyl-, [2R-[1(2S*,3R*),2Alpha,5Beta]]- (9Ci) is a high-purity, stereochemically defined fluorinated pyrrolidine derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate). Its complex chiral structure makes it an essential building block for synthesizing sophisticated active pharmaceutical ingredients, particularly in the development of central nervous system (CNS) and antiviral therapeutics. This compound is primarily targeted at research institutions and pharmaceutical manufacturers engaged in process chemistry, medicinal chemistry, and the scale-up of novel drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Development & Scale-up: Serves as a critical raw material for developing and scaling robust, GMP-compliant manufacturing routes for APIs.
• Asymmetric Synthesis: Utilized as a scaffold or reagent in stereoselective synthesis due to its defined stereocenters.
• Fluorine Chemistry Applications: The fluorine atom incorporated in its structure is leveraged to modulate the metabolic stability, bioavailability, and binding affinity of final drug compounds.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	Pyrrolidine, 1-(2-Fluoro-3-Methyl-1-Oxopentyl)-2,5-Dimethyl-, [2R-[1(2S*,3R*),2Alpha,5Beta]]- (9Ci)
CAS No.	136734-72-0
Molecular Formula	C12H22FNO2
Molecular Weight	231.31 g/mol
Synonyms	1-(2-Fluoro-3-methyl-1-oxopentyl)-2,5-dimethylpyrrolidine; (2R,5S)-1-[(2S,3R)-2-Fluoro-3-methylpentanoyl]-2,5-dimethylpyrrolidine; 2,5-Dimethyl-1-(2-fluoro-3-methyl-1-oxopentyl)pyrrolidine; Fluorinated pyrrolidine derivative; Chiral fluorinated ketone; Advanced fluorinated intermediate; CAS 136734-72-0
EINECS	Contact for details

Quality Control

Every batch of our Pyrrolidine, 1-(2-Fluoro-3-Methyl-1-Oxopentyl)-2,5-Dimethyl-, [2R-[1(2S*,3R*),2Alpha,5Beta]]- (9Ci) is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and stereochemical integrity, meeting the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) including results for assay, chiral purity, and impurity profile (by HPLC/GC) is supplied with each shipment. Our quality commitment aligns with cGMP principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use to prevent evaporation and potential concentration changes. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.