Description

1,2-Bis((2R,5R)-2,5-Di-I-Propylphospholano)Ethane(Cyclooctadiene)Rhodium(I) Tetrafluoroborate is a highly specialized, chiral rhodium-based organometallic catalyst. This compound matters for its exceptional enantioselectivity and catalytic efficiency in asymmetric hydrogenation and other transition metal-catalyzed reactions. It is critically needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of chiral intermediates and active ingredients. The product is supplied with a CAS number of 136705-72-1.

Application

• Asymmetric Hydrogenation Catalyst: For the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical synthesis.
• Pharmaceutical Intermediate Production: Enables the synthesis of chiral building blocks for active pharmaceutical ingredients (APIs), including β-amino acids and unnatural amino acids.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Manufacturing: Catalyzes key steps in the production of flavors, fragrances, and advanced materials requiring high optical purity.
• Academic & Industrial R&D: A valuable tool for method development and exploring new catalytic transformations in organic chemistry.
• Process Chemistry Optimization: Employed for scaling up enantioselective reactions from laboratory to pilot plant and commercial production.

Basic Information

Product Name	1,2-Bis((2R,5R)-2,5-Di-I-Propylphospholano)Ethane(Cyclooctadiene)Rhodium(I) Tetrafluoroborate
CAS No.	136705-72-1
Molecular Formula	C30H56BF4P2Rh
Molecular Weight	664.43 g/mol
Synonyms	(R,R)-Et-DuPhos Rh(COD)BF4; [Rh((R,R)-Et-DuPhos)(COD)]BF4; (R,R)-1,2-Bis(2,5-diethylphospholano)ethane(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; Rhodium(I)-(R,R)-1,2-bis(2,5-diethylphospholano)ethane(1,5-cyclooctadiene) tetrafluoroborate; DuPhos Rh Catalyst; (R,R)-Et-DuPhos-Rh(COD)BarF; Asymmetric Hydrogenation Catalyst Rh-Et-DuPhos; Chiral Rhodium DuPhos Complex
EINECS	Contact for details

Quality Control

Every batch of our chiral catalyst is synthesized and handled under strict inert atmosphere conditions to preserve activity and enantiopurity. Rigorous quality testing ensures compliance with specifications critical for reproducible asymmetric synthesis. Certificates of Analysis (COA) are provided, detailing key parameters such as Rhodium content, enantiomeric excess of ligand, and purity by NMR. Our quality system supports development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (argon or nitrogen) in a cool, dry place. This material is hygroscopic and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will degrade catalytic performance.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline solid or powder
Identification (NMR)	Conforms to structure
Purity (NMR)	≥ 95%
Rhodium Content	~14.5 - 15.5%
Solubility	Soluble in dichloromethane, acetone; sparingly soluble in toluene

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.