Description

Ethyl 2-Methyl-4,4,4-Trifluorobutyrate is a high-value fluorinated ester building block, prized for its unique trifluoromethyl group which imparts desirable properties like enhanced metabolic stability and lipophilicity to target molecules. This compound is essential for synthetic chemists developing advanced materials and active pharmaceutical ingredients (APIs) where fluorine substitution is critical. It serves as a key intermediate for research and production in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in the development of protease inhibitors, anti-inflammatory agents, and other bioactive molecules containing a trifluoromethyl motif.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atoms contribute to improved biological activity, stability, and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic displays and organic light-emitting diodes, enhancing performance characteristics.
• Flavor & Fragrance Chemistry: Acts as an intermediate for creating complex, high-value aroma chemicals with unique organoleptic properties.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, improving properties such as chemical resistance, thermal stability, and surface characteristics.
• Organic Synthesis & Research: A versatile reagent in academic and industrial R&D labs for constructing complex organic frameworks via reactions like alkylation, condensation, and cyclization.

Basic Information

Product Name	Ethyl 2-Methyl-4,4,4-Trifluorobutyrate
CAS No.	136564-76-6
Molecular Formula	C7H11F3O2
Molecular Weight	184.16 g/mol
Synonyms	Ethyl 2-Methyl-4,4,4-Trifluorobutanoate; 4,4,4-Trifluoro-2-methylbutyric Acid Ethyl Ester; 2-Methyl-4,4,4-Trifluorobutyric Acid Ethyl Ester; Butanoic acid, 4,4,4-trifluoro-2-methyl-, ethyl ester; Ethyl 4,4,4-Trifluoro-2-methylbutyrate; Ethyl α-Methyl-4,4,4-Trifluorobutyrate
EINECS	Contact for details

Quality Control

Our Ethyl 2-Methyl-4,4,4-Trifluorobutyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for critical applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to minimize moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (20°C)	1.3750 - 1.3850
Density (20°C)	1.15 - 1.25 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.