Description

(R)-(1-((1-Methylpiperidin-2-Yl)Methyl)-1H-Indol-3-Yl)(Naphthalen-1-Yl)Methanone is a high-purity chiral organic compound featuring a complex molecular architecture that combines indole and naphthalene moieties. This compound is of significant value in advanced pharmaceutical research and development, particularly for its potential as a key synthetic intermediate or a pharmacologically active scaffold. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, especially within the fields of neuroscience and oncology. The precise stereochemistry and high purity are critical for ensuring reproducible results in sensitive biological assays and synthetic pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of potential drug candidates targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of new chemical entities.
• Biochemical Tool Compound: Employed in vitro and in vivo to probe specific biological pathways and protein interactions due to its unique structural features.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in API (Active Pharmaceutical Ingredient) manufacturing.
• Asymmetric Synthesis: Utilized in chiral synthesis protocols where its defined (R)-configuration is essential for creating enantiomerically pure final products.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.

Basic Information

Product Name	(R)-(1-((1-Methylpiperidin-2-Yl)Methyl)-1H-Indol-3-Yl)(Naphthalen-1-Yl)Methanone
CAS No.	134959-64-1
Molecular Formula	C26H26N2O
Molecular Weight	382.50 g/mol
Synonyms	(R)-1-(1-Methyl-2-piperidinylmethyl)-3-(1-naphthoyl)indole; (R)-1-[(1-Methyl-2-piperidinyl)methyl]-3-(1-naphthoyl)indole; (R)-Mepiprapim; (R)-Enantiomer of a cannabinoid receptor ligand; (R)-1-[(1-Methylpiperidin-2-yl)methyl]-3-(naphthalene-1-carbonyl)-1H-indole; (R)-WIN 55,212-3; (R)-WIN 55,212-3 Methanone derivative
EINECS	Contact for details

Quality Control

Every batch of (R)-(1-((1-Methylpiperidin-2-Yl)Methyl)-1H-Indol-3-Yl)(Naphthalen-1-Yl)Methanone is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for chiral purity, chemical purity, and residual solvents. We adhere to cGMP principles where applicable to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep the container sealed to protect this light-sensitive material from degradation. For long-term storage, consider inert gas purging or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.