Description

Cyclobutanecarboxylic Acid, 2-Methyl-, Methyl Ester, (1S,2R)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its value lies in the rigid cyclobutane ring and defined stereochemistry, which are crucial for constructing complex molecular architectures with specific three-dimensional properties. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly where spatial orientation is critical for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides where the specific stereochemistry can influence potency and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce enantioselectivity in chemical reactions.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials that require constrained, rigid molecular backbones.
• Chemical Biology Probes: Utilized to build molecular probes for studying enzyme mechanisms and protein-ligand interactions due to its defined three-dimensional structure.
• Fragrance and Flavor Chemistry: Acts as an intermediate for synthesizing complex, stereoisomerically pure fragrance and flavor molecules.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 2-Methyl-, Methyl Ester, (1S,2R)- (9Ci)
CAS No.	134877-12-6
Molecular Formula	C7H12O2
Molecular Weight	128.17 g/mol
Synonyms	(1S,2R)-2-Methylcyclobutanecarboxylic acid methyl ester; Methyl (1S,2R)-2-methylcyclobutanecarboxylate; (1S,2R)-Methyl 2-methylcyclobutanecarboxylate; (1S,2R)-2-Methylcyclobutanecarboxylic acid methyl ester; trans-(1S,2R)-Methyl 2-methylcyclobutanecarboxylate; (1S,2R)-rel-2-Methylcyclobutanecarboxylic Acid Methyl Ester; Methyl trans-2-methylcyclobutanecarboxylate (stereospecific)
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, which is critical for downstream synthesis. Quality is verified through comprehensive analytical techniques including chiral HPLC, GC, and NMR spectroscopy. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.