Description

n-(3-Ethoxycarbonyloxirane-2-Carbonyl)-Isoleucyl-Proline is a specialized synthetic peptide derivative, primarily recognized as a key intermediate in advanced pharmaceutical synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel therapeutic agents. It is essential for research institutions and pharmaceutical manufacturers focused on peptide-based drug discovery, proteomics research, and the synthesis of enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for protease inhibitor candidates.
• Peptide-Based Drug Discovery: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new peptide therapeutics.
• Biochemical Research: Serves as a substrate or inhibitor analog in enzymatic studies and proteomics research to understand biological pathways.
• Chemical Biology Tool: Employed in the design and synthesis of molecular probes for investigating protein-protein interactions and cellular signaling.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	n-(3-Ethoxycarbonyloxirane-2-Carbonyl)-Isoleucyl-Proline
CAS No.	134447-97-5
Molecular Formula	C16H24N2O7
Molecular Weight	356.38 g/mol
Synonyms	Ethyl 2-[(2S)-2-[[(2S,3S)-2-Amino-3-methylpentanoyl]amino]-1-oxo-3-pyrrolidinyl]-2-oxiraneacetate; Isoleucyl-Proline Oxirane Derivative; N-(3-Ethoxycarbonyl-2-oxiranylcarbonyl)isoleucylproline; (2S)-2-[(2S,3S)-2-[[(2S)-1-Oxo-3-pyrrolidinyl]amino]-3-methylpentanoyl]-2-oxiraneacetic Acid Ethyl Ester; Proline, N-[N-[(2S,3S)-2-amino-3-methyl-1-oxopentyl]-L-isoleucyl]-, 2-oxiraneacetate (ester); CAS 134447-97-5
EINECS	Contact for details

Quality Control

Our n-(3-Ethoxycarbonyloxirane-2-Carbonyl)-Isoleucyl-Proline is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.