Description

6,8-Dioxa-3-azabicyclo[3.2.1]octane-7-carbonyl chloride, 3-methyl-2-oxo-, (1R-exo)- (9Ci) is a high-value, specialized bicyclic heterocyclic building block featuring a reactive acid chloride functional group. This compound is critical for synthetic chemists as it enables the efficient introduction of a complex, constrained molecular scaffold into target molecules, facilitating the development of novel compounds with specific three-dimensional properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for use in medicinal chemistry, process development, and the synthesis of advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of new drugs targeting the central nervous system or infectious diseases.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and structure-activity relationship (SAR) studies to explore novel chemical space and improve pharmacokinetic properties.
• Agrochemical Research: Intermediate in the development of new herbicides, fungicides, or insecticides that require complex, bioactive heterocyclic cores.
• Peptidomimetic Synthesis: Serves as a constrained scaffold to mimic peptide secondary structures, useful in designing enzyme inhibitors or receptor modulators.
• Material Science Research: Potential monomer or cross-linking agent for creating polymers with unique thermal or mechanical properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific advanced intermediates on a commercial scale.

Basic Information

Product Name	6,8-Dioxa-3-azabicyclo[3.2.1]octane-7-carbonyl chloride, 3-methyl-2-oxo-, (1R-exo)- (9Ci)
CAS No.	134255-73-5
Molecular Formula	C8H10ClNO4
Molecular Weight	219.62 g/mol
Synonyms	(1R-exo)-3-Methyl-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carbonyl chloride; 3-Methyl-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carbonyl chloride, (1R-exo)-; Bicyclo[3.2.1]octane-7-carbonyl chloride, 6,8-dioxa-3-aza-3-methyl-2-oxo-, (1R-exo)-; (1R,5S)-3-Methyl-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carbonyl chloride; 7-Chlorocarbonyl-3-methyl-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane, (1R-exo)-
EINECS	Contact for details

Quality Control

Our 6,8-Dioxa-3-azabicyclo[3.2.1]octane-7-carbonyl chloride, 3-methyl-2-oxo-, (1R-exo)- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.