Description

1,4-Epoxy-2-Formamido 1,2,3,4-Tetrahydro-6-Trifluoromethylnaphthalene is a specialized, high-value trifluoromethylated naphthalene derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its unique molecular architecture, featuring both an epoxy and a formamido functional group, makes it a versatile building block for constructing complex, fluorinated target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where the introduction of a trifluoromethyl group is a key strategy for modulating the biological activity, metabolic stability, and lipophilicity of lead compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) drugs, anti-inflammatory agents, and oncology therapeutics where the CF3 group enhances drug-like properties.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group to improve efficacy and environmental profile.
• Material Science: Serves as a monomer or functional additive in the research of specialty polymers and advanced materials, such as fluorinated liquid crystals or coatings with unique surface properties.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex, polycyclic frameworks via ring-opening reactions of the epoxy group and further transformations of the formamido moiety.
• Fluorine Chemistry Studies: A valuable compound for methodological development in fluorination chemistry and for studying the stereoelectronic effects of the trifluoromethyl group in polycyclic systems.

Basic Information

Product Name	1,4-Epoxy-2-Formamido 1,2,3,4-Tetrahydro-6-Trifluoromethylnaphthalene
CAS No.	134254-13-0
Molecular Formula	C₁₃H₁₂F₃NO₂
Molecular Weight	271.24 g/mol
Synonyms	6-(Trifluoromethyl)-1,2,3,4-tetrahydro-1,4-epoxy-2-naphthalenecarboxamide; 1,4-Epoxy-2-formamido-1,2,3,4-tetrahydro-6-(trifluoromethyl)naphthalene; 2-Formamido-1,4-epoxy-1,2,3,4-tetrahydro-6-trifluoromethylnaphthalene; 1,4-Epoxy-2-carbamoyl-1,2,3,4-tetrahydro-6-trifluoromethylnaphthalene; N-(1,4-Epoxy-1,2,3,4-tetrahydro-6-trifluoromethyl-2-naphthyl)formamide; Advanced Trifluoromethyl Naphthalene Epoxide Intermediate
EINECS	Contact for details

Quality Control

Every batch of 1,4-Epoxy-2-Formamido 1,2,3,4-Tetrahydro-6-Trifluoromethylnaphthalene is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.