Description

Cyclobutanecarboxylic Acid, 3-Ethylidene-2-Methyl-, Methyl Ester, [1R- is a high-purity, chiral cyclobutane derivative serving as a critical synthetic intermediate. Its unique fused-ring structure and defined stereochemistry make it an invaluable building block for constructing complex molecular architectures. This compound is essential for research and development in the pharmaceutical and advanced materials sectors, where precise control over molecular geometry is paramount.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the cyclobutane ring contributes to unique biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a sophisticated scaffold for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or cross-linking agent for producing polymers with specific thermal and mechanical properties.
• Fragrance and Flavor Chemistry: Potential intermediate for synthesizing macrocyclic musks and other complex aroma chemicals.
• Academic and R&D: A valuable tool for methodological studies in organic chemistry, including ring-opening and functionalization reactions.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3-Ethylidene-2-Methyl-, Methyl Ester, [1R-
CAS No.	134175-99-8
Molecular Formula	C9H14O2
Molecular Weight	154.21 g/mol
Synonyms	(1R)-3-Ethylidene-2-methyl-cyclobutanecarboxylic acid methyl ester; Methyl (1R)-3-ethylidene-2-methylcyclobutanecarboxylate; [1R-(1α)]-3-Ethylidene-2-methyl-cyclobutanecarboxylic Acid Methyl Ester; (R)-Methyl 3-ethylidene-2-methylcyclobutanecarboxylate; 3-Ethylidene-2-methylcyclobutanecarboxylic acid methyl ester, (1R)-; Chiral cyclobutane ester; Cyclobutane carboxylate derivative
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 3-Ethylidene-2-Methyl-, Methyl Ester, [1R- is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and chiral integrity for your critical applications. Certificates of Analysis (COA) detailing chiral purity (enantiomeric excess), chemical purity by GC/HPLC, and residual solvent levels are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Assay (GC/HPLC)	≥ 97.0%
Chiral Purity (ee)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.