Description

(2,2,2-Trifluoroethoxy)Acetonitrile is a versatile fluorinated building block characterized by its reactive nitrile group and trifluoroethoxy side chain. This compound is essential for introducing fluorine-containing motifs into target molecules, which can dramatically alter their physical, chemical, and biological properties. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated heterocycles and active pharmaceutical ingredients (APIs), leveraging fluorine's ability to enhance metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the trifluoroethoxy group can improve efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, where fluorine atoms help tune dielectric anisotropy and improve performance.
• Polymer Modification: Employed to introduce fluorinated segments into polymers, enhancing properties like chemical resistance, thermal stability, and surface characteristics.
• Organic Synthesis Building Block: Utilized in nucleophilic substitution, cyclization, and cross-coupling reactions to incorporate the -CH2CN moiety alongside fluorine atoms.
• Fluorinated Surfactant & Lubricant Research: Acts as a starting material for creating specialty chemicals with unique surface-active or lubricating properties.

Basic Information

Item	Details
Product Name	(2,2,2-Trifluoroethoxy)Acetonitrile
CAS No.	133915-26-1
Molecular Formula	C4H4F3NO
Molecular Weight	139.07 g/mol
Synonyms	2-(2,2,2-Trifluoroethoxy)acetonitrile; 2,2,2-Trifluoroethyl Cyanomethyl Ether; α-Cyano-2,2,2-trifluoroethyl Methyl Ether (incorrect but sometimes used); Glycolonitrile, 2-(2,2,2-trifluoroethoxy)-; TFEOA; Trifluoroethoxyacetonitrile; Acetonitrile, (2,2,2-trifluoroethoxy)-
EINECS	Contact for details

Quality Control

Our (2,2,2-Trifluoroethoxy)Acetonitrile is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation to ensure it meets the high standards required for research and scale-up. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in opaque secondary packaging.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.