Description

Cyclobutanecarboxaldehyde, 2-(1-Methoxyethyl)-, [1Alpha,2Beta(S*)]- (9Ci) is a chiral, functionalized cyclobutane derivative, a high-value intermediate prized for its unique stereochemistry and reactive aldehyde group. This compound matters for its role as a sophisticated building block in the synthesis of complex, biologically active molecules, enabling precise control over three-dimensional structure. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by fine chemical manufacturers specializing in custom synthesis and process development. The product is supplied under high-purity conditions to ensure optimal performance in sensitive synthetic applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in areas requiring complex carbocyclic or constrained structures.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the cyclobutane ring and specific stereochemistry contribute to unique biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce enantioselectivity.
• Fragrance and Flavor Chemistry: Potential use as an intermediate for synthesizing novel aroma chemicals with unique olfactory properties derived from its aldehyde functionality and ring strain.
• Material Science Research: Investigated as a monomer or cross-linking agent for producing polymers with specific thermal or mechanical properties due to the strained four-membered ring.
• Academic and R&D Laboratories: Employed in methodological studies and the total synthesis of natural products, providing a versatile chiral aldehyde handle for carbon-carbon bond formation.

Basic Information

Product Name	Cyclobutanecarboxaldehyde, 2-(1-Methoxyethyl)-, [1Alpha,2Beta(S*)]- (9Ci)
CAS No.	133868-31-2
Molecular Formula	C8H14O2
Molecular Weight	142.20 g/mol
Synonyms	(1S,2R)-2-[(1S)-1-Methoxyethyl]cyclobutanecarbaldehyde; (1S,2R)-2-[(S)-1-Methoxyethyl]cyclobutanecarboxaldehyde; [1α,2β(S*)]-2-(1-Methoxyethyl)cyclobutanecarboxaldehyde; 2-[(1S)-1-Methoxyethyl]-(1S,2R)-cyclobutanecarbaldehyde; Chiral 2-(1-Methoxyethyl)cyclobutanecarboxaldehyde; (1S,2R)-rel-2-[(1S)-1-Methoxyethyl]cyclobutanecarboxaldehyde
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxaldehyde, 2-(1-Methoxyethyl)-, [1Alpha,2Beta(S*)]- (9Ci) is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, identity confirmation by IR and NMR spectroscopy, and quantitative assay to ensure high chemical and isomeric purity. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment. We adhere to cGMP principles for advanced intermediates, ensuring traceability, consistency, and reliability for our global B2B clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This product is easily oxidized and light-sensitive. Allow the container to reach ambient temperature before opening to minimize moisture ingress and condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.