Description

Cyclobutanecarboxaldehyde, 2-(1-Methoxyethyl)-, [1R-[1Alpha,2Alpha(S*)]]- (9Ci) is a chiral, high-purity chemical building block characterized by its cyclobutane and aldehyde functional groups. This compound is valued for its precise stereochemistry, making it a critical intermediate in the synthesis of complex, biologically active molecules. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for applications in asymmetric synthesis and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral targets.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where specific stereochemistry is required for optimal biological activity.
• Asymmetric Catalysis: Serves as a precursor or ligand in the development of chiral catalysts for enantioselective reactions.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fragrance compounds and other specialty chemicals.
• Academic & Industrial Research: A valuable reagent for methodological studies in organic chemistry, exploring new cyclobutane-based transformations.

Basic Information

Product Name	Cyclobutanecarboxaldehyde, 2-(1-Methoxyethyl)-, [1R-[1Alpha,2Alpha(S*)]]- (9Ci)
CAS No.	133868-13-0
Molecular Formula	C8H14O2
Molecular Weight	142.20 g/mol
Synonyms	(1R,2S)-2-[(1S)-1-Methoxyethyl]cyclobutanecarboxaldehyde; (1R,2S)-2-[(S)-1-Methoxyethyl]cyclobutanecarbaldehyde; [1R-(1α,2α(S*))]-2-(1-Methoxyethyl)cyclobutanecarboxaldehyde; (1R,2S)-2-(1-Methoxyethyl)cyclobutanecarbaldehyde; Chiral Cyclobutane Aldehyde Derivative; 2-(1-Methoxyethyl)cyclobutanecarboxaldehyde (stereospecific)
EINECS	Contact for details

Quality Control

Every batch of this chiral aldehyde is produced and analyzed under strict quality management systems. We guarantee high chiral purity and chemical integrity, with specifications typically covering identity, assay, enantiomeric excess (e.e.), and related substances. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from advanced analytical techniques like chiral HPLC, GC, and NMR. Our quality commitment supports compliance with cGMP and ISO 9001 standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen) in a cool, dry place at 2-8°C for long-term stability. This material is easily oxidized and light-sensitive; allow the sealed container to reach ambient temperature before opening to minimize moisture ingress and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.