Description

1-Bromo-2,3,5-Trifluorobenzene is a high-purity halogenated aromatic building block essential for advanced organic synthesis. Its unique trifluoromethyl and bromo substituents make it a versatile intermediate for introducing fluorine atoms and enabling cross-coupling reactions. This compound is primarily utilized by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials industries to develop novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorine-containing drug candidates targeting CNS, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorine-based compounds for electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine atom acts as an effective handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Fluorine Chemistry Research: An important reagent in academic and industrial R&D for studying structure-activity relationships (SAR) and developing new fluorination methodologies.
• Polymer & Material Science: Employed in the synthesis of fluorinated polymers and specialty coatings that require enhanced chemical resistance, thermal stability, and low surface energy.

Basic Information

Product Name	1-Bromo-2,3,5-Trifluorobenzene
CAS No.	133739-70-5
Molecular Formula	C6H2BrF3
Molecular Weight	210.98 g/mol
Synonyms	2,3,5-Trifluorobromobenzene; 2-Bromo-1,3,5-Trifluorobenzene; Benzene, 1-bromo-2,3,5-trifluoro-; 1,3,5-Trifluoro-2-bromobenzene; 2,3,5-Trifluoro-1-bromobenzene; 2-Bromo-1,3,5-trifluorobenzene; 1-Bromo-2,3,5-trifluorobenzol
EINECS	Contact for details

Quality Control

Our 1-Bromo-2,3,5-Trifluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. Certificates of Analysis (COA) with full traceability are provided for every shipment, and we support compliance with relevant regulatory frameworks such as REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture ingress and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.8 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.