Description

trans-4-(Trifluoromethyl)Cyclohexanecarbaldehyde is a high-value, versatile fluorinated aldehyde building block used in advanced organic synthesis. Its unique structure, featuring a rigid cyclohexane ring and a reactive aldehyde group, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries seeking to incorporate the trifluoromethyl group, which can significantly alter a molecule's metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display technologies, contributing to improved dielectric anisotropy and thermal stability.
• Advanced Polymer Chemistry: Incorporated as a monomer or cross-linking agent to create specialty polymers with enhanced chemical resistance, low surface energy, and unique optical properties.
• Catalyst & Ligand Development: Employed in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial R&D for exploring new fluorination methodologies and the structure-activity relationships of fluorinated compounds.

Basic Information

Product Name	trans-4-(Trifluoromethyl)Cyclohexanecarbaldehyde
CAS No.	133261-34-4
Molecular Formula	C8H11F3O
Molecular Weight	180.17 g/mol
Synonyms	trans-4-(Trifluoromethyl)cyclohexanecarboxaldehyde; 4-(Trifluoromethyl)cyclohexanecarbaldehyde (trans-); 4-(Trifluoromethyl)cyclohexanecarboxaldehyde; (trans)-4-(Trifluoromethyl)cyclohexanecarbaldehyde; 4-(Trifluoromethyl)cyclohexanecarbaldehyde; 133261-34-4; Cyclohexanecarboxaldehyde, 4-(trifluoromethyl)-, trans-; 4-Trifluoromethylcyclohexanecarbaldehyde
EINECS	Contact for details

Quality Control

Our trans-4-(Trifluoromethyl)Cyclohexanecarbaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and isomeric consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP, ISO, and REACH standards for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C/59-77°F) under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from heat, sparks, open flames, and incompatible materials such as strong oxidizing agents, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Isomeric Purity (trans-)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.