Description

3'',5''-Difluoro-4''-Hydroxyacetophenone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular structure, featuring strategically placed fluorine atoms and a reactive acetophenone core, makes it a valuable precursor for creating complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of fluorinated drug candidates, particularly in areas like kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides, where the fluorine atoms can enhance biological activity, metabolic stability, and lipophilicity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, where fluorine substitution can improve charge transport, thermal stability, and optical properties.
• Advanced Polymer Chemistry: Employed to introduce fluorine-containing side chains into polymers, potentially modifying surface properties, chemical resistance, and dielectric constants.
• Chemical Research & Development: A versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and the exploration of new chemical spaces in academic and industrial labs.
• Fluorinated Dye & Pigment Intermediate: Can be utilized in the synthesis of specialized dyes and pigments where fluorine atoms alter light absorption and color fastness.

Basic Information

Product Name	3'',5''-Difluoro-4''-Hydroxyacetophenone
CAS No.	133186-55-7
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	1-(3,5-Difluoro-4-hydroxyphenyl)ethan-1-one; 3,5-Difluoro-4-hydroxyacetophenone; 4'-Hydroxy-3',5'-difluoroacetophenone; 4-Acetyl-2,6-difluorophenol; 2,6-Difluoro-4-acetylphenol; 1-(4-Hydroxy-3,5-difluorophenyl)ethanone; Ethanone, 1-(3,5-difluoro-4-hydroxyphenyl)-
EINECS	Contact for details

Quality Control

Our 3'',5''-Difluoro-4''-Hydroxyacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.