Description

Z-3-Chloro-1-(2-Chlorophenyl)-2-(4-Fluorophenyl)-Oxirane is a high-purity chiral epoxide building block of significant importance in advanced organic synthesis. Its value lies in its precise stereochemistry and functional group arrangement, making it a critical intermediate for constructing complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel therapeutic agents, including potential central nervous system (CNS) and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its halogenated aromatic structure contributes to biological activity.
• Asymmetric Catalysis Research: Serves as a valuable substrate or ligand precursor in the study and development of new stereoselective catalytic reactions.
• Material Science Precursor: Employed in the synthesis of specialized polymers or liquid crystals that require specific chiral and halogenated monomers.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Details
Product Name	Z-3-Chloro-1-(2-Chlorophenyl)-2-(4-Fluorophenyl)-Oxirane
CAS No.	133024-33-6
Molecular Formula	C14H9Cl2FO
Molecular Weight	283.13 g/mol
Synonyms	(Z)-3-Chloro-1-(2-chlorophenyl)-2-(4-fluorophenyl)oxirane; (Z)-2-(4-Fluorophenyl)-3-chloro-1-(2-chlorophenyl)oxirane; 1-(2-Chlorophenyl)-2-(4-fluorophenyl)-3-chlorooxirane (Z-isomer); trans-3-Chloro-1-(2-chlorophenyl)-2-(4-fluorophenyl)oxirane; Z-3-Chloro-1-(2-chlorophenyl)-2-(4-fluorophenyl)oxirane; 133024-33-6; Oxirane, 3-chloro-1-(2-chlorophenyl)-2-(4-fluorophenyl)-, (2R,3S)-rel-; A chiral epoxide intermediate
EINECS	Contact for details

Quality Control

Our Z-3-Chloro-1-(2-Chlorophenyl)-2-(4-Fluorophenyl)-Oxirane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard identification and purity assays. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.