Description

3'-Fluoro-4'-Methoxy-2,2,2-Trifluoroacetophenone is a high-value, multi-fluorinated aromatic ketone building block essential for advanced organic synthesis. Its unique trifluoroacetyl and substituted phenyl structure makes it a critical intermediate for introducing fluorinated motifs, which are prized for their ability to modulate the lipophilicity, metabolic stability, and bioavailability of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing trifluoromethyl ketone pharmacophores.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorinated components in electronic display technologies.
• Organic Light-Emitting Diodes (OLEDs): Employed in the synthesis of electron-transport or host materials for improved device efficiency.
• Advanced Material Research: Utilized in academic and industrial R&D for creating novel fluorinated polymers and specialty chemicals.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions for constructing complex, fluorinated biaryl systems.

Basic Information

Product Name	3'-Fluoro-4'-Methoxy-2,2,2-Trifluoroacetophenone
CAS No.	132734-54-4
Molecular Formula	C9H6F4O2
Molecular Weight	222.14 g/mol
Synonyms	1-(3-Fluoro-4-methoxyphenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(3-fluoro-4-methoxyphenyl)ethanone; 3-Fluoro-4-methoxy-α,α,α-trifluoroacetophenone; 3-Fluoro-4-methoxy-2,2,2-trifluoroacetophenone; 3'-Fluoro-4'-methoxy-α,α,α-trifluoroacetophenone; TFAP-F-OMe derivative; Fluorinated Trifluoroacetophenone Derivative
EINECS	Contact for details

Quality Control

Our 3'-Fluoro-4'-Methoxy-2,2,2-Trifluoroacetophenone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as verified by HPLC, GC, NMR, and IR spectroscopy. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.