Description

[S,(-)]-2-Hydroxy-4-Phenyl-3-Butenenitrile CAS NO 132617-10-8 is a high-purity chiral intermediate characterized by its specific stereochemistry at the 2-position. This compound is valued for its role in the synthesis of optically active pharmaceuticals and fine chemicals, where enantiomeric purity is critical for efficacy and safety. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for developing novel active ingredients and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in central nervous system and cardiovascular drug candidates.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides, where the specific stereoisomer can enhance biological activity and reduce environmental impact.
• Asymmetric Catalysis: Serves as a precursor or ligand in the development of chiral catalysts for stereoselective organic transformations.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring high enantiomeric excess.
• Academic & Industrial Research: A valuable reagent for methodological development in organic synthesis and stereochemistry studies within R&D laboratories.

Basic Information

Product Name	[S,(-)]-2-Hydroxy-4-Phenyl-3-Butenenitrile
CAS No.	132617-10-8
Molecular Formula	C10H9NO
Molecular Weight	159.19 g/mol
Synonyms	(S)-2-Hydroxy-4-phenyl-3-butenenitrile; (S)-(-)-2-Hydroxy-4-phenyl-3-butenenitrile; (2S)-2-Hydroxy-4-phenylbut-3-enenitrile; (S)-2-Hydroxy-4-phenylbut-3-enenitrile; (S)-α-Hydroxycinnamonitrile; (S)-O-Hydroxycinnamonitrile; (S)-2-Hydroxy-4-phenyl-3-butenenitrile; (S)-Form
EINECS	Contact for details

Quality Control

Our [S,(-)]-2-Hydroxy-4-Phenyl-3-Butenenitrile is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess determination, to ensure it meets the high-purity standards required for synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and chiral purity are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider the use of a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.