Description

α-Methyl-4-[4-(Dimethylcarbamoyl)-2-Thiazolyl]Benzeneacetic Acid is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate of significant commercial and research importance. This compound is a critical building block in the synthesis of advanced pharmaceutical actives, particularly for its role as a key precursor to potent COX-2 inhibitors. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the development of next-generation analgesic and anti-inflammatory therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of selective COX-2 inhibitor drugs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of novel anti-inflammatory agents.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Process Chemistry: Utilized in scale-up and optimization studies for API (Active Pharmaceutical Ingredient) manufacturing processes.
• Custom Synthesis: A starting material for the custom synthesis of specialized derivatives and analogs for biological screening.

Basic Information

Product Name	α-Methyl-4-[4-(Dimethylcarbamoyl)-2-Thiazolyl]Benzeneacetic Acid
CAS No.	132483-52-4
Molecular Formula	C15H16N2O3S
Molecular Weight	304.36 g/mol
Synonyms	2-[4-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)phenyl]propionic acid; 4-[4-(Dimethylcarbamoyl)-2-thiazolyl]-α-methylbenzeneacetic acid; Valdecoxib intermediate; SC-65872 (intermediate); COX-2 inhibitor intermediate; Benzeneacetic acid, α-methyl-4-[4-(dimethylamino)carbonyl]-2-thiazolyl]-; 4-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-α-methylbenzenepropanoic acid
EINECS	Contact for details

Quality Control

Our α-Methyl-4-[4-(Dimethylcarbamoyl)-2-Thiazolyl]Benzeneacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediate use. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.