Description

2-Bromo-1-Pyrazin-2-Ylethanone is a versatile and highly reactive brominated heterocyclic building block. This compound is valued for its role as a key electrophilic intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing pyrazine or related heterocyclic cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require functionalized pyrazine structures.
• Chemical Biology & Proteomics: Serves as a reactive handle for activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysis, and other functional organic compounds.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various palladium-catalyzed cross-coupling reactions to form new carbon-carbon bonds.
• Library Synthesis for Drug Discovery: A valuable building block for the parallel and combinatorial synthesis of diverse compound libraries for high-throughput screening.

Basic Information

Product Name	2-Bromo-1-Pyrazin-2-Ylethanone
CAS No.	132426-19-8
Molecular Formula	C6H5BrN2O
Molecular Weight	201.02 g/mol
Synonyms	2-Bromo-1-(pyrazin-2-yl)ethanone; 2-Bromo-1-(2-pyrazinyl)ethanone; 2-Pyrazinyl Bromomethyl Ketone; α-Bromo-2-pyrazinyl methyl ketone; 2-Bromo-2-pyrazin-1-ylethanone; Bromomethyl 2-pyrazinyl ketone; 2-Acetylpyrazine, 2-bromo-
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-Pyrazin-2-Ylethanone is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality systems are designed to support cGMP compliance for use in regulated research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent degradation. Handle and store in accordance with all applicable local and international regulations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.