Description

p-[[(1S)-2-[4-(Benzoylamino)-2-Oxo-1(2H)-Pyrimidinyl]-1-(Hydroxymethyl)Ethoxy]Methyl]Phosphonic Acid Diethyl Ester CAS NO 132336-36-8 is a high-purity, chiral phosphonate derivative of a pyrimidine nucleoside analog, serving as a critical advanced pharmaceutical intermediate. Its primary value lies in enabling the synthesis of complex antiviral and anticancer agents, where its specific stereochemistry and functional groups are essential for biological activity. This compound is vital for research institutions and pharmaceutical manufacturers engaged in the development of next-generation nucleotide-based therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antiviral prodrugs, particularly for hepatitis B (HBV) and hepatitis C (HCV) treatments.
• Anticancer Agent Research: Used in the development of nucleotide analogs that target DNA/RNA synthesis in cancer cells.
• ProTide Technology: A crucial component in the ProTide (Phosphoramidate Prodrug) approach to improve the cellular delivery and efficacy of nucleoside monophosphates.
• Medicinal Chemistry: Serves as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-Up: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for kilogram-to-ton scale GMP manufacturing campaigns.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to viral polymerases and other nucleic acid-processing enzymes.

Basic Information

Product Name	p-[[(1S)-2-[4-(Benzoylamino)-2-Oxo-1(2H)-Pyrimidinyl]-1-(Hydroxymethyl)Ethoxy]Methyl]Phosphonic Acid Diethyl Ester
CAS No.	132336-36-8
Molecular Formula	C20H26N3O7P
Molecular Weight	451.41 g/mol
Synonyms	(S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate; Tenofovir Alafenamide Intermediate; GS-7340 Intermediate; Phosphonic acid, P-[[(1S)-2-[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-1-(hydroxymethyl)ethoxy]methyl]-, diethyl ester; 1-(2-(((Diethoxyphosphoryl)methoxy)methyl)-3-hydroxypropyl)-4-(benzamido)pyrimidin-2(1H)-one; BOC Sciences BD-0-008; Ambeed A271285.
EINECS	Contact for details

Quality Control

Our p-[[(1S)-2-[4-(Benzoylamino)-2-Oxo-1(2H)-Pyrimidinyl]-1-(Hydroxymethyl)Ethoxy]Methyl]Phosphonic Acid Diethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to support your regulatory filings and ensure supply chain reliability.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Single Maximum Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.