Description

1-(2-Methylnaphthyl) Trifluoromethyl Ketone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the trifluoromethyl ketone group adjacent to the naphthyl system, enabling precise molecular construction. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries seeking to incorporate fluorinated motifs for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Research: Used in the synthesis of advanced herbicides and fungicides, where the fluorine atoms can improve lipophilicity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Employed in the research of fluorinated polymers and liquid crystals with unique optical and electronic properties.
• Fluorine Chemistry Studies: A valuable model compound for investigating nucleophilic addition and reduction reactions of polyfluorinated ketones.

Basic Information

Product Name	1-(2-Methylnaphthyl) Trifluoromethyl Ketone
CAS No.	131831-98-6
Molecular Formula	C₁₃H₉F₃O
Molecular Weight	238.21 g/mol
Synonyms	2'-Methyl-1-naphthyl trifluoromethyl ketone; 1-(2-Methyl-1-naphthyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(2-methyl-1-naphthyl)ethanone; α,α,α-Trifluoro-2'-methylacetophenone; 2-Methylnaphthalen-1-yl trifluoromethyl ketone; (2-Methyl-1-naphthyl)(trifluoromethyl)methanone
EINECS	Contact for details

Quality Control

Our 1-(2-Methylnaphthyl) Trifluoromethyl Ketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.