Description

3',5'-Bis(Trifluoromethyl)-2-Bromoacetophenone is a high-value, multi-functional organic building block characterized by its bromoacetyl and bis(trifluoromethyl)phenyl groups. This compound matters for its role as a critical intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research, where the introduction of fluorine atoms and reactive halogen sites is essential for modulating bioactivity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, inflammation, and oncology, where the trifluoromethyl groups enhance metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in developing advanced herbicides, fungicides, and insecticides, leveraging the fluorine atoms to improve weatherfastness, lipophilicity, and overall efficacy.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of novel fluorinated polymers, liquid crystals, and organic electronic materials due to its unique electronic properties.
• Chemical Biology Probes: Utilized to create activity-based probes and fluorogenic substrates for studying enzyme mechanisms and cellular processes.
• Custom Synthesis and Contract Manufacturing: A vital building block for custom synthesis houses serving the life sciences industry for producing target molecules at various scales.

Basic Information

Product Name	3',5'-Bis(Trifluoromethyl)-2-Bromoacetophenone
CAS No.	131805-94-2
Molecular Formula	C10H5BrF6O
Molecular Weight	335.05 g/mol
Synonyms	2-Bromo-1-[3,5-bis(trifluoromethyl)phenyl]ethanone; 1-[3,5-Bis(trifluoromethyl)phenyl]-2-bromoethanone; 2-Bromo-3',5'-bis(trifluoromethyl)acetophenone; α-Bromo-3,5-bis(trifluoromethyl)acetophenone; 3,5-Bis(trifluoromethyl)phenacyl bromide; 2-Bromo-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-one
EINECS	Contact for details

Quality Control

Our 3',5'-Bis(Trifluoromethyl)-2-Bromoacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged operations to maintain stability. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.