Description

Thiamethoxam Impurity 1 is a high-purity chemical reference standard used for analytical and research purposes. This compound is critical for quality control and regulatory compliance in the agrochemical and pharmaceutical industries, where precise impurity profiling is essential. It is primarily required by analytical laboratories, manufacturers of thiamethoxam, and regulatory bodies for method development, validation, and batch release testing.

Application

• Analytical Reference Standard: Used as a certified standard in HPLC, LC-MS, and GC-MS for the accurate quantification of Thiamethoxam Impurity 1 in active pharmaceutical ingredients (APIs) and technical-grade materials.
• Pharmaceutical Impurity Profiling: Essential for identifying, characterizing, and controlling this specific impurity in thiamethoxam-based drug substances to meet ICH Q3A/B guidelines.
• Agrochemical Quality Assurance: Employed in the quality control of thiamethoxam pesticide formulations to ensure product safety, efficacy, and compliance with FAO and EPA specifications.
• Method Development and Validation: Serves as a critical component in developing and validating analytical methods for impurity detection and separation.
• Regulatory Submissions: Provides necessary data for drug master files (DMFs), pesticide dossiers, and other regulatory documentation requiring full impurity characterization.
• Research and Development: Used in metabolic, stability, and degradation studies to understand the formation and behavior of this impurity.

Basic Information

Product Name	Thiamethoxam Impurity 1
CAS No.	131748-59-9
Molecular Formula	C8H10ClN5O3S
Molecular Weight	291.71 g/mol
Synonyms	N-(2-Chloro-1,3-thiazol-5-ylmethyl)-N'-methyl-N''-nitroguanidine; 3-[(2-Chloro-1,3-thiazol-5-yl)methyl]-5-methyl-1-nitro-1,3,5-triazinan-2-imine; Thiamethoxam Impurity A; Thiamethoxam Related Compound A; Thiamethoxam Nitroso Impurity; Thiamethoxam Metabolite; NTG; Thiamethoxam Nitrosoguanidine Derivative
EINECS	Contact for details

Quality Control

Every batch of Thiamethoxam Impurity 1 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of identity, purity, and stability. Our quality system is designed to support regulatory requirements, providing full traceability and documentation. A comprehensive Certificate of Analysis (COA) is supplied with each shipment, detailing results for assay, related substances, residual solvents, and other critical parameters as per client specifications or in-house standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.