Description

4-Bromopyridine-2-Carbaldehyde is a versatile and high-value brominated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique bifunctional structure, featuring both a bromo substituent and an aldehyde group, makes it an indispensable precursor for constructing complex heterocyclic frameworks and pharmaceutical intermediates. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its reactive sites for structural diversification.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Building block for creating organic electronic materials, such as components for OLEDs or conductive polymers.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille), while the aldehyde allows for further functionalization.

Basic Information

Product Name	4-Bromopyridine-2-Carbaldehyde
CAS No.	131747-63-2
Molecular Formula	C6H4BrNO
Molecular Weight	186.01 g/mol
Synonyms	2-Formyl-4-bromopyridine; 4-Bromo-2-pyridinecarboxaldehyde; 4-Bromopicolinaldehyde; 4-Bromo-2-formylpyridine; 2-Pyridinecarboxaldehyde, 4-bromo-; 4-Bromopyridine-2-carboxaldehyde; 4-Bromo-2-pyridylaldehyde; 4-Bromopicolinal
EINECS	Contact for details

Quality Control

Our 4-Bromopyridine-2-Carbaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider packaging under an inert atmosphere such as nitrogen or argon. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.