Description

1-Fluorohomocitrate is a fluorinated derivative of homocitric acid, a key intermediate in the biosynthesis of lysine and other metabolites. This specialized fluorinated compound is of significant interest in biochemical research and pharmaceutical development, particularly for studying enzyme mechanisms and metabolic pathways. It serves as a valuable building block for medicinal chemists and researchers in the life sciences, enabling the synthesis of novel analogs and probes.

Application

• Biochemical Research: Used as a stable, fluorinated analog to investigate the function and inhibition of enzymes in the homocitrate synthase and related metabolic pathways.
• Pharmaceutical Intermediates: Serves as a key synthetic precursor for the development of novel fluorinated drug candidates and bioactive molecules.
• Metabolic Pathway Studies: Acts as a tracer or inhibitor in studies of lysine biosynthesis and other primary metabolic processes in microorganisms and plants.
• Enzyme Mechanism Probes: Utilized to elucidate catalytic mechanisms of aconitase-family enzymes due to the fluorine atom's ability to mimic a hydroxyl group while altering reactivity.
• Academic & Industrial R&D: Employed in discovery chemistry and life science research within university laboratories, biotech, and pharmaceutical R&D departments.

Basic Information

Product Name	1-Fluorohomocitrate
CAS No.	131736-83-9
Molecular Formula	C7H9FO7
Molecular Weight	224.14 g/mol
Synonyms	1-Fluorohomocitric acid; (1R,2S)-1-Fluoro-1,2,3-propanetricarboxylic acid; 1-Fluoro-1,2,3-propanetricarboxylic acid; Homocitric acid, 1-fluoro-; Fluorohomocitric acid
EINECS	Contact for details

Quality Control

Our 1-Fluorohomocitrate is produced and tested under strict quality management protocols. We provide material suitable for research and development purposes, with typical purity levels exceeding 95% (by HPLC). Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We are committed to meeting the specific purity and documentation requirements of our global research and industrial partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation by atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.