Description

2-(Bicyclo[1.1.1]pentan-1-yl)acetic acid is a specialized bicyclic carboxylic acid building block of significant interest in advanced organic synthesis. Its unique, highly strained [1.1.1]propellane-derived structure makes it a valuable precursor for creating novel three-dimensional molecular architectures. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel drug candidates with enhanced three-dimensional properties, potentially improving bioavailability and target selectivity.
• Agrochemical Research: Used in the development of new active ingredients with unique modes of action, leveraging its strained bicyclic core.
• Material Science Precursor: Serves as a monomer or cross-linking agent for creating polymers with specific mechanical or thermal properties.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Academic & Industrial R&D: A valuable tool for methodological studies in organic synthesis, particularly in strain-release chemistry and C–H functionalization.

Basic Information

Product Name	2-(Bicyclo[1.1.1]pentan-1-yl)acetic acid
CAS No.	131515-31-6
Molecular Formula	C7H10O2
Molecular Weight	126.15 g/mol
Synonyms	2-(Bicyclo[1.1.1]pentan-1-yl)ethanoic acid; [1.1.1]Propellane-1-acetic acid; 2-(1-Bicyclo[1.1.1]pentanyl)acetic acid; Bicyclo[1.1.1]pentane-1-acetic acid; 1-Acetic acid bicyclo[1.1.1]pentane; (Bicyclo[1.1.1]pentan-1-yl)acetic acid
EINECS	Contact for details

Quality Control

Our 2-(Bicyclo[1.1.1]pentan-1-yl)acetic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.