Description

(3-Bromoprop-1-Yn-1-Yl)(tert-Butyl)Dimethylsilane is a high-value organosilicon building block featuring both a bromoalkyne and a silyl protecting group. This compound matters for its versatility in advanced organic synthesis, enabling precise molecular construction through cross-coupling and click chemistry reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, particularly those requiring alkyne functionalization for bioconjugation or further derivatization.
• Agrochemical Synthesis: Used in the research and development of novel active ingredients, leveraging the reactive bromoalkyne moiety for structural diversification.
• Material Science Research: Serves as a precursor for functionalized polymers, dendrimers, and surface coatings where the alkyne group enables controlled polymerization or attachment to surfaces.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Click Chemistry: The terminal alkyne is ideal for copper-catalyzed azide-alkyne cycloaddition (CuAAC), a cornerstone reaction in bioconjugation and polymer science.
• Protecting Group Strategy: The tert-butyldimethylsilyl (TBDMS) group protects the alkyne, allowing for selective reactions at other sites in a molecule, with subsequent deprotection under mild conditions.

Basic Information

Product Name	(3-Bromoprop-1-Yn-1-Yl)(tert-Butyl)Dimethylsilane
CAS No.	131365-11-2
Molecular Formula	C9H17BrSi
Molecular Weight	233.22 g/mol
Synonyms	3-Bromo-1-(tert-butyldimethylsilyl)-1-propyne; 1-Bromo-3-(tert-butyldimethylsilyl)propyne; (3-Bromoprop-1-yn-1-yl)-tert-butyldimethylsilane; TBDMS-Protected 3-Bromopropyne; tert-Butyl(3-bromoprop-1-yn-1-yl)dimethylsilane; Silane, (3-bromo-1-propyn-1-yl)(1,1-dimethylethyl)dimethyl-; 3-Bromoprop-1-yn-1-yl-tert-butyldimethylsilane
EINECS	Contact for details

Quality Control

Our (3-Bromoprop-1-Yn-1-Yl)(tert-Butyl)Dimethylsilane is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.