Description

3-Isoxazolecarboxaldehyde, 4,5-Dihydro-4-Methyl-5-(1-Methylethyl)-, cis- (9Ci) is a specialized heterocyclic aldehyde building block of significant interest in advanced organic synthesis. Its unique cis-fused bicyclic structure containing the isoxazole and dihydrofuran rings makes it a valuable precursor for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS and anti-infective agents.
• Agrochemical Synthesis: Serves as a building block for novel herbicides, fungicides, and insecticides, leveraging its reactive aldehyde group for further functionalization.
• Ligand and Catalyst Development: Used in academic and industrial research to create novel chiral ligands and organocatalysts for asymmetric synthesis.
• Material Science Research: Employed as a monomer or cross-linking agent in the development of specialty polymers with unique optical or electronic properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Item	Details
Product Name	3-Isoxazolecarboxaldehyde, 4,5-Dihydro-4-Methyl-5-(1-Methylethyl)-, cis- (9Ci)
CAS No.	131362-99-7
Molecular Formula	C9H13NO2
Molecular Weight	167.21 g/mol
Synonyms	cis-4,5-Dihydro-4-methyl-5-(1-methylethyl)-3-isoxazolecarboxaldehyde; 4,5-Dihydro-4-methyl-5-isopropyl-3-isoxazolecarboxaldehyde, cis-; 4-Methyl-5-isopropyl-4,5-dihydroisoxazole-3-carbaldehyde; (4R,5S)-4-Methyl-5-(propan-2-yl)-4,5-dihydro-1,2-oxazole-3-carbaldehyde (enantiomer); (4S,5R)-4-Methyl-5-(propan-2-yl)-4,5-dihydro-1,2-oxazole-3-carbaldehyde (enantiomer); Isoxazole aldehyde derivative; Dihydroisoxazole carboxaldehyde.
EINECS	Contact for details

Quality Control

Our 3-Isoxazolecarboxaldehyde, 4,5-Dihydro-4-Methyl-5-(1-Methylethyl)-, cis- (9Ci) is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure consistent identity, purity, and performance. Certificates of Analysis (COA) detailing specific chromatographic and spectroscopic data are provided with each shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (cis-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.