Description

L-Allo-S-Phenyl-Ss-Methylcysteine CAS NO 131235-00-2 is a specialized, non-proteinogenic amino acid derivative featuring a unique stereochemical configuration and a phenylmethylthioether side chain. This compound is of significant value in advanced pharmaceutical research and development, particularly in the synthesis of novel peptide-based therapeutics and enzyme inhibitors. It serves as a critical chiral building block for medicinal chemists and process development scientists working in drug discovery, enabling the exploration of new chemical entities with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in oncology and metabolic disease research.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate modified cysteine analogs, influencing peptide conformation, stability, and receptor binding.
• Protease Inhibitor Design: Serves as a core structural component in the design of selective cysteine protease inhibitors, relevant for treating parasitic and viral infections.
• Chemical Biology Probes: Employed in the development of activity-based probes (ABPs) to study enzyme function and mechanism in complex biological systems.
• Asymmetric Synthesis Catalyst Ligand: Potential use as a precursor for chiral ligands or organocatalysts in asymmetric synthesis, facilitating the production of enantiomerically pure compounds.
• Academic & Institutional Research: A valuable reagent for universities and research institutes studying sulfur amino acid metabolism, redox biology, and novel bio-conjugation techniques.

Basic Information

Product Name	L-Allo-S-Phenyl-Ss-Methylcysteine
CAS No.	131235-00-2
Molecular Formula	C10H13NO2S
Molecular Weight	211.28 g/mol
Synonyms	(2S)-2-Amino-3-[(phenylmethyl)sulfanyl]propanoic acid; L-Allo-S-Benzylcysteine; S-Benzyl-L-cysteine (allo form); (S)-2-Amino-3-(benzylthio)propanoic acid; L-α-Amino-β-(benzylthio)propionic acid (allo); NSC 403914; BRN 2208443; β-(Benzylthio)-L-alanine (allo)
EINECS	Contact for details

Quality Control

Our L-Allo-S-Phenyl-Ss-Methylcysteine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for all critical parameters, supporting cGMP-compliant development work. Our quality commitment ensures material integrity for your most demanding research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to prevent oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (L-allo isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.