Description

Dirhodium Tetrakis[n-Phthaloyl-(S)-Phenylalaninate] Ethyl Acetate Adduct is a high-purity, chiral dirhodium(II) carboxylate complex widely recognized as a premier catalyst for asymmetric carbenoid transformations. Its primary value lies in enabling highly enantioselective C-H insertion, cyclopropanation, and ylide formation reactions, which are critical for constructing complex chiral molecules with high fidelity. This product is essential for research and development chemists in the pharmaceutical and fine chemical industries seeking to streamline the synthesis of active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Asymmetric C-H Functionalization: A key catalyst for enantioselective intramolecular and intermolecular C-H insertion reactions to form C-C bonds.
• Enantioselective Cyclopropanation: Used in the synthesis of chiral cyclopropane rings, a privileged scaffold in medicinal chemistry.
• Pharmaceutical Intermediate Synthesis: Critical for the production of chiral building blocks and advanced intermediates in API development.
• Ylide Formation and Rearrangement: Facilitates asymmetric X-H insertion reactions (e.g., Si-H, N-H) for the synthesis of complex molecules.
• Methodology Development: A standard catalyst in academic and industrial R&D for developing new asymmetric catalytic processes.
• Fine Chemical Production: Employed in the scalable manufacture of high-value, enantiomerically pure flavors, fragrances, and agrochemicals.

Basic Information

Item	Details
Product Name	Dirhodium Tetrakis[n-Phthaloyl-(S)-Phenylalaninate] Ethyl Acetate Adduct
CAS No.	131219-55-1
Molecular Formula	C68H56N4O16Rh2 • xC4H8O2
Molecular Weight	~1440.94 (anhydrous basis)
Synonyms	Dirhodium(II) Tetrakis[N-phthaloyl-(S)-phenylalaninate]; Rh2(S-PTA)4; Dirhodium(II) (S)-N-Phthaloylphenylalaninate; Dirhodium(II) Tetrakis[(S)-N-(1,3-Dioxoisoindolin-2-yl)-3-phenylpropanamide]; Dirhodium(II) Carboxylate Catalyst; Chiral Dirhodium Catalyst; Asymmetric Dirhodium Catalyst; Rh2(S-PTAD)4
EINECS	Contact for details

Quality Control

Every batch of our Dirhodium Tetrakis[n-Phthaloyl-(S)-Phenylalaninate] Ethyl Acetate Adduct is manufactured under strict quality management systems. We perform comprehensive analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and ICP-MS for trace metal analysis, to ensure consistent performance and high catalytic activity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Green to blue-green crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0% (anhydrous basis)
Chiral Purity (HPLC)	≥ 99.0% ee
Solvent Content (Ethyl Acetate)	≤ 10.0% (by 1H NMR)
Rhodium Content (ICP-MS)	13.5 - 14.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.