Description

(4-Fluorophenylethynyl)Trimethylsilane is a versatile organosilicon building block featuring a fluorinated aromatic alkyne moiety protected by a trimethylsilyl (TMS) group. This compound matters for its dual functionality, serving as a key intermediate in the synthesis of complex molecules for advanced materials and pharmaceuticals. It is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for constructing carbon frameworks and introducing fluorine atoms into target structures.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorinated aromatic acetylene units via Sonogashira and other cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating molecular libraries for screening.
• Fluorine Chemistry: Acts as a stable, protected source of a fluorinated arylacetylene unit for various fluorination and functionalization strategies.
• Ligand Synthesis: Used in the preparation of sophisticated ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	(4-Fluorophenylethynyl)Trimethylsilane
CAS No.	130995-12-9
Molecular Formula	C11H13FSi
Molecular Weight	192.31 g/mol
Synonyms	1-Fluoro-4-[(trimethylsilyl)ethynyl]benzene; 4-(Trimethylsilylethynyl)fluorobenzene; p-Fluorophenyl(trimethylsilyl)acetylene; Trimethyl[(4-fluorophenyl)ethynyl]silane; 4-Fluorophenylethynyltrimethylsilane; TMS-Protected 4-Fluorophenylacetylene; 4-Fluoroethynylbenzene trimethylsilyl derivative
EINECS	Contact for details

Quality Control

Our (4-Fluorophenylethynyl)Trimethylsilane is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee reliable performance in your sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.