Description

Ethanone, 2,2,2-Trifluoro-1-(2-Phenylcyclopropyl)-, (1S-Trans)- (9Ci) CAS NO 130888-10-7 is a high-purity, chiral trifluoromethyl ketone derivative featuring a unique phenylcyclopropyl backbone. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate, enabling the synthesis of complex molecules with precise stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the creation of advanced, optically active pesticides and herbicides where the specific stereochemistry influences biological activity.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in academic and industrial research focused on developing new catalytic methodologies.
• Material Science: Acts as a specialty monomer or precursor for synthesizing polymers and advanced materials with specific optical or electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways, leveraging its fluorinated ketone functionality.

Basic Information

Product Name	Ethanone, 2,2,2-Trifluoro-1-(2-Phenylcyclopropyl)-, (1S-Trans)- (9Ci)
CAS No.	130888-10-7
Molecular Formula	C11H9F3O
Molecular Weight	214.18 g/mol
Synonyms	(1S-trans)-2,2,2-Trifluoro-1-(2-phenylcyclopropyl)ethanone; (1S,2S)-2,2,2-Trifluoro-1-(2-phenylcyclopropyl)ethanone; (1S-trans)-2,2,2-Trifluoro-1-(2-phenylcyclopropyl)ethan-1-one; 2,2,2-Trifluoro-1-[(1S,2S)-2-phenylcyclopropyl]ethanone; (1S,2S)-2,2,2-Trifluoro-1-(2-phenylcyclopropyl)ethan-1-one; (1S,2S)-2,2,2-Trifluoroacetophenone cyclopropane derivative; trans-2-Phenylcyclopropyl trifluoromethyl ketone (1S,2S isomer)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide comprehensive analytical data to support your R&D and production needs. Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles are available for every batch. Our quality systems are designed to meet the stringent requirements of pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.