Description

1,6,7,8-Indolizinetetrol, Octahydro-, 1-Benzoate, 1S-(1.Alpha.,6.Beta.,7.Alpha.,8.Beta.,8A.Beta.)- is a complex, stereochemically defined indolizine derivative that serves as a critical advanced intermediate in organic synthesis. Its precise stereochemistry and functional groups make it a valuable scaffold for constructing pharmacologically active molecules, particularly in the development of complex natural product analogs and chiral pharmaceuticals. This compound is primarily sought by research institutions and pharmaceutical companies engaged in the synthesis of novel bioactive compounds, where high purity and stereochemical integrity are paramount.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex alkaloids and other nitrogen-containing heterocycles with potential therapeutic activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of new drug candidates targeting neurological or metabolic pathways.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric reactions due to its multiple stereocenters.
• Natural Product Synthesis: A crucial intermediate in the total or semi-synthesis of indolizidine and related classes of natural products.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme function or biological pathways.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1,6,7,8-Indolizinetetrol, Octahydro-, 1-Benzoate, 1S-(1.Alpha.,6.Beta.,7.Alpha.,8.Beta.,8A.Beta.)-
CAS No.	130446-84-3
Molecular Formula	C15H20O5
Molecular Weight	280.32 g/mol
Synonyms	(1S,6R,7S,8R,8aR)-Octahydro-1,6,7,8-indolizinetetrol 1-benzoate; 1,6,7,8-Tetrahydroxyoctahydroindolizine-1-carboxylic acid phenyl ester; 1-O-Benzoyl-DMDP; 1-O-Benzoyldihydroxymethyldihydroxypyrrolidine; 1-O-Benzoyl-2,5-dideoxy-2,5-imino-D-glucitol; 1-O-Benzoyl-2,5-dideoxy-2,5-imino-D-mannitol; 1-O-Benzoyl-DMDP derivative; Indolizidine polyol benzoate
EINECS	Contact for details

Quality Control

Our production of 1,6,7,8-Indolizinetetrol, Octahydro-, 1-Benzoate, 1S-(1.Alpha.,6.Beta.,7.Alpha.,8.Beta.,8A.Beta.)- adheres to stringent quality protocols suitable for research and pharmaceutical development. Each batch is characterized and tested to ensure high stereochemical purity and chemical identity. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with every shipment. We support compliance with ICH guidelines for stability and impurity characterization upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.