Description

4,7-Difluoro-2,3-Dihydro-1H-Inden-1-Ol is a fluorinated indanol derivative, a versatile chiral building block prized for its unique structural motif in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of active pharmaceutical ingredients (APIs) and high-value fine chemicals, enabling the introduction of fluorine atoms and a rigid, fused-ring system. Pharmaceutical, agrochemical, and advanced material research and development teams need it to create novel compounds with enhanced biological activity and physical properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoro-substituted indane core can improve metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and liquid crystals, where its rigid, fluorinated structure can influence material properties.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in regulatory and research laboratories.

Basic Information

Product Name	4,7-Difluoro-2,3-Dihydro-1H-Inden-1-Ol
CAS No.	130408-17-2
Molecular Formula	C9H8F2O
Molecular Weight	170.16 g/mol
Synonyms	4,7-Difluoro-1-indanol; 4,7-Difluoro-2,3-dihydro-1H-inden-1-ol; 1H-Inden-1-ol, 4,7-difluoro-2,3-dihydro-; 4,7-Difluoroindan-1-ol; (±)-4,7-Difluoro-2,3-dihydro-1H-inden-1-ol; rac-4,7-Difluoroindan-1-ol
EINECS	Contact for details

Quality Control

Our 4,7-Difluoro-2,3-Dihydro-1H-Inden-1-Ol is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (or as specified)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.