Description

3',5'-Dichloro-2,2,2-Trifluoroacetophenone is a high-purity, halogenated aromatic ketone building block of significant importance in advanced organic synthesis. Its unique structure, featuring both chlorine and fluorine substituents, makes it a critical intermediate for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers seeking to introduce trifluoromethyl and dichloro-substituted phenyl motifs into target structures, enabling the fine-tuning of biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic displays and organic light-emitting diodes (OLEDs).
• Advanced Polymer Chemistry: Employed as a monomer or modifier to create specialty polymers with enhanced chemical resistance, thermal stability, and unique optical properties.
• Chemical Research & Development: A versatile building block in medicinal chemistry and material science R&D for structure-activity relationship (SAR) studies and novel compound libraries.
• Fluorinated Surfactant & Dye Intermediate: Used in the synthesis of specialty surfactants and dyes that require specific solubility and surface activity profiles.

Basic Information

Product Name	3',5'-Dichloro-2,2,2-Trifluoroacetophenone
CAS No.	130336-16-2
Molecular Formula	C8H3Cl2F3O
Molecular Weight	243.01 g/mol
Synonyms	1-(3,5-Dichlorophenyl)-2,2,2-trifluoroethanone; 3,5-Dichloro-α,α,α-trifluoroacetophenone; 2,2,2-Trifluoro-1-(3,5-dichlorophenyl)ethanone; 3,5-Dichlorophenyl trifluoromethyl ketone; 3,5-Dichloro-α,α,α-trifluoroacetophenone; 1-(3,5-Dichlorophenyl)-2,2,2-trifluoro-1-ethanone; 3,5-Dichloro-ω,ω,ω-trifluoroacetophenone
EINECS	Contact for details

Quality Control

Our 3',5'-Dichloro-2,2,2-Trifluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is sensitive to strong alkalis and fluorides; ensure segregation from incompatible substances. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.