Description

3-Bromo-5-Fluoro-2-Hydroxybenzotrifluoride is a high-value, multi-functional halogenated aromatic building block. This compound matters for its unique trifluoromethyl and halogen substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of advanced molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials due to its aromatic core and halogen functionalities.
• Chemical Research & Development: Employed in academic and industrial labs for method development, catalysis studies, and exploring novel organic reactions involving halogenated aromatics.
• Fluorine Chemistry Studies: An important compound for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in molecular design.

Basic Information

Product Name	3-Bromo-5-Fluoro-2-Hydroxybenzotrifluoride
CAS No.	130046-84-3
Molecular Formula	C7H3BrF4O
Molecular Weight	258.99 g/mol
Synonyms	2-Hydroxy-3-bromo-5-fluorobenzotrifluoride; 3-Bromo-5-fluoro-2-(trifluoromethyl)phenol; 2-(Trifluoromethyl)-3-bromo-5-fluorophenol; 3-Bromo-5-fluoro-alpha,alpha,α-trifluoro-o-cresol; 3-Bromo-5-fluoro-α,α,α-trifluoro-o-cresol; 5-Fluoro-3-bromo-2-hydroxybenzotrifluoride; Benzotrifluoride, 3-bromo-5-fluoro-2-hydroxy-
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Fluoro-2-Hydroxybenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.