Description

4'-Chloro-3'-(trifluoromethyl)acetophenone is a high-value fluorinated aromatic ketone building block, essential for synthesizing advanced chemical intermediates. Its unique structure, featuring both chloro and trifluoromethyl substituents, provides critical electronic and steric properties for developing novel active compounds. This product is primarily targeted at research and development teams in the pharmaceutical and agrochemical industries, where it serves as a key precursor for creating new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic display technologies.
• Advanced Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, altering their surface properties, chemical resistance, and thermal stability.
• Organic Synthesis & Catalysis Research: A versatile reagent in academic and industrial R&D for constructing complex molecules and exploring new catalytic transformations.
• Fluorinated Dye & Pigment Intermediate: Used in the production of specialty dyes and pigments where fluorine substitution modifies color fastness and solubility.

Basic Information

Product Name	4'-Chloro-3'-(Trifluoromethyl)Acetophenone
CAS No.	129825-11-2
Molecular Formula	C9H6ClF3O
Molecular Weight	222.59 g/mol
Synonyms	1-[4-Chloro-3-(trifluoromethyl)phenyl]ethanone; 4'-Chloro-α,α,α-trifluoro-3'-methylacetophenone; 4-Chloro-3-trifluoromethylacetophenone; 3'-Trifluoromethyl-4'-chloroacetophenone; 4-Chloro-α,α,α-trifluoro-m-acetophenone; 1-(4-Chloro-3-(trifluoromethyl)phenyl)ethan-1-one; p-Chloro-m-(trifluoromethyl)acetophenone
EINECS	Contact for details

Quality Control

Our production of 4'-Chloro-3'-(trifluoromethyl)acetophenone adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, NMR, and IR spectroscopy. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support custom synthesis and can tailor specifications to meet specific project requirements under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents. The container should be kept tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.