Description

5-Trifluoromethyl-2H-Pyrazole-3-Carboxylic Acid Ethyl Ester is a high-value fluorinated pyrazole derivative, a crucial synthetic intermediate prized for its trifluoromethyl group which imparts desirable metabolic stability and lipophilicity to target molecules. Its primary commercial value lies in enabling the efficient synthesis of advanced agrochemicals and pharmaceuticals, particularly those requiring a robust heterocyclic scaffold. This compound is essential for R&D and production chemists in the life sciences sector seeking to develop novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a critical precursor for developing new-generation herbicides, fungicides, and insecticides, where the trifluoromethylpyrazole moiety enhances bioactivity and environmental persistence.
• Material Science Research: Used in the development of specialty chemicals, ligands for catalysis, and advanced organic electronic materials due to its unique electronic properties.
• Chemical Biology & Proteomics: Employed as a scaffold for designing enzyme inhibitors, molecular probes, and tagged compounds for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in bespoke synthesis projects and scale-up campaigns.

Basic Information

Product Name	5-Trifluoromethyl-2H-Pyrazole-3-Carboxylic Acid Ethyl Ester
CAS No.	129768-30-5
Molecular Formula	C7H7F3N2O2
Molecular Weight	208.14 g/mol
Synonyms	Ethyl 5-(Trifluoromethyl)-1H-pyrazole-3-carboxylate; 5-(Trifluoromethyl)-1H-pyrazole-3-carboxylic acid ethyl ester; 3-Ethoxycarbonyl-5-trifluoromethylpyrazole; 1H-Pyrazole-3-carboxylic acid, 5-(trifluoromethyl)-, ethyl ester; Ethyl 5-trifluoromethyl-1H-pyrazole-3-carboxylate
EINECS	Contact for details

Quality Control

Every batch of 5-Trifluoromethyl-2H-Pyrazole-3-Carboxylic Acid Ethyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA), including results from HPLC, NMR, and GC-MS, is supplied with each shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.