Description

Dimethyl-[2-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzyl]-Amine is a specialized organoboron compound featuring a benzylamine scaffold protected by a pinacol boronic ester group. This matters because it serves as a versatile and stable synthetic intermediate, enabling the introduction of amine and arylboronate functionalities in complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in Suzuki-Miyaura cross-coupling reactions and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring aryl-amine linkages.
• Suzuki-Miyaura Cross-Coupling: Acts as a stable boronic ester coupling partner for the palladium-catalyzed formation of carbon-carbon bonds with aryl halides.
• Medicinal Chemistry & Library Synthesis: Enables rapid diversification and structure-activity relationship (SAR) studies in drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Material Science Research: Potential monomer or precursor for functional polymers and advanced organic materials.
• Ligand Synthesis: Can be utilized to create novel chelating ligands for catalysis.

Basic Information

Product Name	Dimethyl-[2-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzyl]-Amine
CAS No.	129636-11-9
Molecular Formula	C15H24BNO2
Molecular Weight	261.17 g/mol
Synonyms	2-[(Dimethylamino)methyl]phenylboronic acid pinacol ester; N,N-Dimethyl-1-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanamine; (2-((Dimethylamino)methyl)phenyl)boronic acid pinacol ester; Dimethyl-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]amine; 2-(Dimethylaminomethyl)phenylboronic acid pinacol ester; B-[2-[(Dimethylamino)methyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our Dimethyl-[2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]-Amine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.