Description

2',4',5'-Trifluoroacetophenone is a high-purity, multi-fluorinated aromatic ketone building block. This compound is valued for its role as a critical intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), advanced materials, and specialty fine chemicals where the introduction of fluorine atoms is required to modulate biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, including kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where fluorination enhances stability and efficacy.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic display and lighting technologies.
• Organic Synthesis & Research: A versatile building block for Friedel-Crafts acylation, Grignard reactions, and other transformations in academic and industrial R&D laboratories.
• Fluorinated Polymer Modifiers: Employed in the synthesis of specialty monomers to create polymers with tailored surface properties and chemical resistance.

Basic Information

Product Name	2',4',5'-Trifluoroacetophenone
CAS No.	129322-83-4
Molecular Formula	C8H5F3O
Molecular Weight	174.12 g/mol
Synonyms	1-(2,4,5-Trifluorophenyl)ethanone; 2,4,5-Trifluoroacetophenone; Ethanone, 1-(2,4,5-trifluorophenyl)-; 2,4,5-Trifluoroacetylbenzene; 2',4',5'-Trifluoroacetylbenzene; α,2,4-Trifluoroacetophenone (incorrect but common); TFAP (abbreviation)
EINECS	Contact for details

Quality Control

Our 2',4',5'-Trifluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0% (Standard Grade)
Purity (HPLC/GC)	≥ 99.0% (High Purity Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.