Description

1-(3-Chloro-4-(Trifluoromethyl)Phenyl)Ethanone is a high-purity, halogenated aromatic ketone building block essential for advanced organic synthesis. Its unique structure, featuring both chloro and trifluoromethyl substituents, makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Active Ingredient Precursor: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl group.
• Liquid Crystal & OLED Material Synthesis: Serves as a building block for advanced electronic materials requiring specific halogenated aromatic cores.
• Organic Ligand & Catalyst Development: Employed in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic & Industrial Research: Used in research laboratories for exploring new chemical reactions and developing novel synthetic methodologies.

Basic Information

Product Name	1-(3-Chloro-4-(Trifluoromethyl)Phenyl)Ethanone
CAS No.	129322-80-1
Molecular Formula	C9H6ClF3O
Molecular Weight	222.59 g/mol
Synonyms	3'-Chloro-4'-(trifluoromethyl)acetophenone; 1-[3-Chloro-4-(trifluoromethyl)phenyl]ethanone; 3-Chloro-α,α,α-trifluoro-p-acetophenone; 3-Chloro-4-trifluoromethylacetophenone; 3-Chloro-4-(trifluoromethyl)acetophenone; 1-Acetyl-3-chloro-4-(trifluoromethyl)benzene; 3-Chloro-α,α,α-trifluoro-4-methylacetophenone
EINECS	Contact for details

Quality Control

Our 1-(3-Chloro-4-(Trifluoromethyl)Phenyl)Ethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.