Description

1-Trimethylsilylpropynl Boronic Ester is a specialized organoboron compound featuring a trimethylsilyl-protected alkyne group. This unique structure makes it a valuable protected boronic acid building block for advanced organic synthesis, particularly in cross-coupling reactions. It is primarily utilized by pharmaceutical and agrochemical R&D teams for constructing complex molecular architectures. The compound's reactivity profile allows for selective transformations that are critical in modern medicinal chemistry.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a key protected boronic ester precursor for forming carbon-carbon bonds in complex molecule synthesis.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), especially those requiring alkyne functionalization.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with specific structural motifs.
• Material Science Research: Employed in the synthesis of organic electronic materials, polymers, and ligands where the alkyne and boronate functionalities are essential.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for bio-conjugation and labeling applications.
• Academic & Industrial R&D: A critical reagent for methodology development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Item	Detail
Product Name	1-Trimethylsilylpropynl Boronic Ester
CAS No.	129217-85-2
Molecular Formula	C9H19BO2Si
Molecular Weight	198.14 g/mol
Synonyms	1-(Trimethylsilyl)-1-propyn-3-ylboronic acid pinacol ester; 1-Trimethylsilyl-1-propyn-3-ylboronic acid pinacol ester; 1-[(Trimethylsilyl)ethynyl]vinylboronic acid pinacol ester; 3-Trimethylsilyl-2-propyn-1-ylboronic acid pinacol ester; TMS-Propargyl Boronic Ester; Pinacol [1-(trimethylsilyl)prop-2-yn-1-yl]boronate; (1-Trimethylsilylprop-2-ynyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-Trimethylsilylpropynl Boronic Ester is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We adhere to industry-standard analytical methods, including NMR, HPLC, and GC, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.