Description

4'-(2-Fluorophenyl)Propiophenone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of a fluorine atom can dramatically alter biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists working on the synthesis of novel active pharmaceutical ingredients (APIs), liquid crystal materials, and functionalized ligands for catalysis.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of fluorinated drug candidates, including potential CNS agents and anti-inflammatory compounds.
• Agrochemical Research: Used in developing novel pesticides and herbicides where fluorination enhances lipophilicity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated mesogens and electron-transport materials in display and lighting technologies.
• Organic Synthesis Building Block: Employed in Friedel-Crafts acylation, Grignard reactions, and reductive amination to create more complex aromatic systems.
• Catalyst & Ligand Development: Useful for synthesizing specialized phosphine or nitrogen-based ligands for transition metal catalysis.
• Academic & Industrial R&D: A valuable reagent for methodological studies in fluoroorganic chemistry and structure-activity relationship (SAR) exploration.

Basic Information

Product Name	4'-(2-Fluorophenyl)Propiophenone
CAS No.	129159-23-5
Molecular Formula	C15H13FO
Molecular Weight	228.26 g/mol
Synonyms	1-(2-Fluorophenyl)-3-phenyl-1-propanone; 2-Fluorophenyl Propiophenone; 3-Phenyl-1-(2-fluorophenyl)-1-propanone; 1-Propanone, 1-(2-fluorophenyl)-3-phenyl-; 4-(2-Fluorophenyl)propiophenone; 2-Fluorophenyl 3-phenylpropyl ketone; 4'-Fluoro-2-phenylpropiophenone (isomer specific); 129159-23-5
EINECS	Contact for details

Quality Control

Our 4'-(2-Fluorophenyl)Propiophenone is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with customer specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.